Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids

Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope high functional group tolerance. Moreover, small complex molecules natural products drugs can be modified by late-stage modification.